The Nomadic Life of a Scientist
Florian Krammer, Nathan Brendish, Irene Gonzalez
Join in on this enthusiastic and insightful conversation between Nathan Brendish, associated with the University of Southampton in the United Kingdom, and Irene Gonzalez and Florian Krammer from the Icahn School of Medicine at Mount Sinai in the United States of America. Explore the joys and sorrows of embarking on a scientific career in this episode as we delve into the nomadic life of scientists as they explore the world in search of new and existing data in the field of respiratory viruses.
Biotechnology graduate by Universitat Politècnica de València, with the M.S.c in Nanoscience and Advanced Nanotechnology. I did my thesis at Universitat Autònoma de Barcelona in Professor Gòdia’s group, focused on characterization and purification of virus-like particles (VLPs). I am proactive, self-driven and hard-working. I enjoy working in dynamic, enriching environments, where I can always keep learning and growing personally and professionally.
Dr Nathan Brendish is a NIHR Clinical Lecturer in Infectious Diseases & General Internal Medicine. His research interests focus on the clinical impact of point-of-care tests for infectious diseases.
Dr Brendish’s expertise in rapid diagnostic tests in severe respiratory virus infection stems from his PhD under Professor Tristan Clark at the University of Southampton. Dr Brendish continues to be part of Prof Clark’s research group.
Dr Brendish was the lead study fellow on the ResPOC trial. The ResPOC trial was a large, pragmatic, randomised controlled trial of routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness versus standard care. This showed that multiplex molecular testing at the point-of-care for respiratory viruses improved diagnosis of influenza, improved appropriate neuraminidase inhibitor prescribing, improved appropriate use of isolation facilities, and decreased length of hospital stay. This seminal study was published in The Lancet Respiratory Medicine in 2017.
Dr Brendish was also the lead fellow for the CoV-19POC trial of molecular point-of-care testing for SARS-CoV-2, which also showed multiple clinical benefits of ultra-rapid PCR testing, and was published in The Lancet Respiratory Medicine in 2020.
Dr Brendish started his research career as a study physician in the NIHR Southampton Clinical Research Facility, focussing on malaria vaccine trials.
Position: Professor of Vaccinology at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai (New York, USA) and Professor of Infection Medicine at the Medical University of Vienna (Austria).
Florian Krammer, PhD, graduated from the University of Natural Resources and Life Sciences, Vienna. He received his postdoctoral training in the laboratory of Dr. Peter Palese at the Icahn School of Medicine at Mount Sinai, New York working on hemagglutinin stalk-based immunity and universal influenza virus vaccines.
In 2014 he became an independent principal investigator and is currently the endowed Mount Sinai Professor of Vaccinology at the Icahn School of Medicine at Mount Sinai. He is also the co-director of the Center for Vaccine Research and Pandemic Preparedness (C-VaRPP). Furthermore, since 2024, Dr. Krammer is Professor for Infection Medicine at the Ignaz Semmelweis Institute at the Medical University of Vienna.
Dr. Krammer's work focuses on understanding the mechanisms of interactions between antibodies and viral surface glycoproteins and on translating this work into novel, broadly protective vaccines and therapeutics. The main target is influenza virus but he is also working on coronaviruses, flaviviruses, hantaviruses, filoviruses and arenaviruses. He has published more than 400 papers on these topics. Since 2019, Dr. Krammer has served as principal investigator of the Sinai-Emory Multi-Institutional Collaborative Influenza Vaccine Innovation Center (SEM-CIVIC), which develops improved seasonal and universal influenza virus vaccines that induce long-lasting protection against drifted seasonal, zoonotic and future pandemic influenza viruses.